Current opinion in otolaryngology & head and neck surgery · 2025
The contemporary role of sinus surgery in managing cystic fibrosis.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lubner Rory J, Beswick Daniel M
Аннотация
PURPOSE OF REVIEW: In this review, we summarize the current state of medical treatment for cystic fibrosis (CF) patients and how cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy has revolutionalized the landscape of CF management, including from a sinonasal perspective. We describe the indications for endoscopic sinus surgery (ESS), perioperative decisions otolaryngologists must consider, and the most effective surgical treatment approaches.
RECENT FINDINGS: Effective CFTR modulator therapy reduces SNOT-22 scores as well as endoscopic and radiographic scores. In this era, surgical indications for people with CF and chronic rhinosinsusitis (CRS) includes persistent, recalcitrant symptoms despite medical interventions, including CFTR therapy. The decision to pursue surgery should incorporate sinus symptoms, as ESS solely for pulmonary function improvement remains controversial. When ESS is performed, extended approaches to the sinuses may be beneficial, although evidence in this area is limited.
SUMMARY: Despite prominent advances in disease modifying therapies, ESS remains a treatment option to manage refractory sinonasal symptoms and CRS in people with CF who do not respond to medical therapy. The decision to pursue ESS remains individualized and should involve a multidisciplinary discussion between clinicians to optimize patient selection, surgical goals, and perioperative medical management.
RECENT FINDINGS: Effective CFTR modulator therapy reduces SNOT-22 scores as well as endoscopic and radiographic scores. In this era, surgical indications for people with CF and chronic rhinosinsusitis (CRS) includes persistent, recalcitrant symptoms despite medical interventions, including CFTR therapy. The decision to pursue surgery should incorporate sinus symptoms, as ESS solely for pulmonary function improvement remains controversial. When ESS is performed, extended approaches to the sinuses may be beneficial, although evidence in this area is limited.
SUMMARY: Despite prominent advances in disease modifying therapies, ESS remains a treatment option to manage refractory sinonasal symptoms and CRS in people with CF who do not respond to medical therapy. The decision to pursue ESS remains individualized and should involve a multidisciplinary discussion between clinicians to optimize patient selection, surgical goals, and perioperative medical management.