Clinical neurophysiology practice · 2026
Acute administration of methylphenidate modulates functional connectivity during irrelevant stimuli processing in Parkinson's disease.
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Li Ling, Bo Tan, Lopez Estela Martinez, Gonzalez Mirian Roson, Fernandez-Del-Olmo Miguel, Gurevich Tanya, Desojo Lydia Vela, Fogelson Noa
Аннотация
OBJECTIVE: Methylphenidate (MPD) may have therapeutic benefits in Parkinson's disease (PD) patients. However, the effects of MPD on attentional functional connectivity (FC) networks, in PD, have not been investigated to date. Our objective was to examine the effects of a single dose of MPD, on event-related FC, in PD. The study was a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial.
METHODS: We recorded electroencephalogram (EEG) in PD patients during the performance of an extended version of a visual oddball task. We evaluated FC during the processing of task-relevant (targets, predictive sequence) and task-irrelevant (randomized standards) stimuli, using the weighted phase-locking index and graph theory. Two recording sessions (20 mg MPD or placebo) were performed in each patient.
RESULTS: MPD, in comparison with placebo, modulated FC during the processing of standards, within the theta band, in PD patients. MPD induced decreases in the FC and global efficiency within fronto-parietal networks, during the processing of task-irrelevant stimuli.
CONCLUSIONS: In PD patients, the administration of a single dose of MPD, compared with placebo, attenuated FC within fronto-parietal networks, during the processing of non-informative standards.
SIGNIFICANCE: MPD may have cognitive therapeutic effects in PD, by modulating attention during the processing of task-irrelevant stimuli.
METHODS: We recorded electroencephalogram (EEG) in PD patients during the performance of an extended version of a visual oddball task. We evaluated FC during the processing of task-relevant (targets, predictive sequence) and task-irrelevant (randomized standards) stimuli, using the weighted phase-locking index and graph theory. Two recording sessions (20 mg MPD or placebo) were performed in each patient.
RESULTS: MPD, in comparison with placebo, modulated FC during the processing of standards, within the theta band, in PD patients. MPD induced decreases in the FC and global efficiency within fronto-parietal networks, during the processing of task-irrelevant stimuli.
CONCLUSIONS: In PD patients, the administration of a single dose of MPD, compared with placebo, attenuated FC within fronto-parietal networks, during the processing of non-informative standards.
SIGNIFICANCE: MPD may have cognitive therapeutic effects in PD, by modulating attention during the processing of task-irrelevant stimuli.