Diabetes/metabolism research and reviews · 2026
Long-Term Risk of Incident Type 2 Diabetes Following SARS-CoV-2 Infection: A Population-Based Study in British Columbia, Canada.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Velásquez García Héctor Alexander, Wong Stanley, Jeong Dahn, Naveed Zaeema, Mahmood Bushra, McKee Geoffrey, Janjua Naveed Zafar
Аннотация
AIMS: To assess the long-term risk of incident type 2 diabetes mellitus (T2DM) following SARS-CoV-2 infection in a large population-based cohort.
MATERIALS AND METHODS: We conducted a retrospective cohort study of all British Columbia residents aged ≥ 18 years tested for SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR) between 1 January 2020 and 31 January 2024. Individuals with pre-existing diabetes or residing in long-term care were excluded. Incident T2DM, identified more than 30 days after testing, was ascertained using a validated administrative algorithm. Inverse probability-weighted cause-specific hazard models estimated adjusted hazard ratios (HRs) for incident diabetes, accounting for death as a competing risk. Subgroup analyses examined associations by sex, age, vaccination status, COVID-19 severity, and follow-up duration.
RESULTS: Among 2,044,421 individuals (296,390 SARS-CoV-2-positive; 1,748,031 negative), 47,704 (2.33%) incident T2DM cases were identified over a median follow-up of 874 days. Compared with the SARS-CoV-2-negative group, the risk of diabetes was higher among infected individuals (HR 1.18; 95% CI: 1.15-1.22; p < 0.0001), rising progressively with illness severity-from ambulatory to hospitalised and intensive-care cases. No evidence of association was found among the vaccinated subgroups. The excess risk persisted for up to 3 years before waning thereafter.
CONCLUSIONS: SARS-CoV-2 infection was associated with an increased risk of incident T2DM that persisted for up to 3 years, particularly among unvaccinated and severely ill individuals. These findings highlight the importance of post-infection metabolic surveillance and the potential protective role of vaccination.
MATERIALS AND METHODS: We conducted a retrospective cohort study of all British Columbia residents aged ≥ 18 years tested for SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR) between 1 January 2020 and 31 January 2024. Individuals with pre-existing diabetes or residing in long-term care were excluded. Incident T2DM, identified more than 30 days after testing, was ascertained using a validated administrative algorithm. Inverse probability-weighted cause-specific hazard models estimated adjusted hazard ratios (HRs) for incident diabetes, accounting for death as a competing risk. Subgroup analyses examined associations by sex, age, vaccination status, COVID-19 severity, and follow-up duration.
RESULTS: Among 2,044,421 individuals (296,390 SARS-CoV-2-positive; 1,748,031 negative), 47,704 (2.33%) incident T2DM cases were identified over a median follow-up of 874 days. Compared with the SARS-CoV-2-negative group, the risk of diabetes was higher among infected individuals (HR 1.18; 95% CI: 1.15-1.22; p < 0.0001), rising progressively with illness severity-from ambulatory to hospitalised and intensive-care cases. No evidence of association was found among the vaccinated subgroups. The excess risk persisted for up to 3 years before waning thereafter.
CONCLUSIONS: SARS-CoV-2 infection was associated with an increased risk of incident T2DM that persisted for up to 3 years, particularly among unvaccinated and severely ill individuals. These findings highlight the importance of post-infection metabolic surveillance and the potential protective role of vaccination.