BMJ public health · 2026
Roles of children, isolation measures and socioeconomic status in SARS-CoV-2 household transmission: a retrospective cohort study in a southern US city.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fairley Jessica K, Leung Serena S, Binion Brianna A, Nowak Kacy D, Lane Morgan A, Mbanya Armand, Carter Jasmine R, Espinoza Daniel O, Collins Matthew H, Glover Felicia, Heaney Christopher D, Pisanic Nora, Kruczynski Kate, Spicer Kristoffer, Ojo-Akosile Tolulope, Breiman Robert F, Anderson Evan J, Lobelo Felipe
Аннотация
OBJECTIVE: There has been significant debate about both the role of children in SARS-CoV-2 community transmission as well as the potential harm or lack thereof of the virus in the paediatric population. We aimed to better understand how children are impacted by a SARS-CoV-2 household infection and to identify behavioural and social factors related to infection.
METHODS: A cross-sectional study was conducted on households with children and a recent SARS-CoV-2 infection in Atlanta, GA. Participants were enrolled from December 2020 through November 2021. Salivary IgG against SARS-CoV-2 spike and nucleocapsid antigens was measured and household and infection data collected and analysed.
RESULTS: 49 households participated, including 121 adults and 57 children with 118 (66%) individuals having been infected with SARS-CoV-2. Mean SARS-CoV-2 secondary infection rate was 0.55 (95% CI 0.41 to 0.69) and median, 0.67 (range 0-1.0). Incidence rate did not differ significantly between households with paediatric versus adult index cases (incidence rate ratio (IRR) 0.97, 95% CI 0.63 to 1.49). However, sharing a bedroom or bathroom was associated with a higher incidence of secondary infection (IRR 2.36, 95% CI 1.49 to 3.74). Neighbourhood deprivation index was associated with higher household SARS-CoV-2 incidence, but this did not reach statistical significance.
CONCLUSIONS: Child index cases appeared as likely to result in household secondary SARS-CoV-2 infections as adult index cases, while sharing rooms was associated with higher incidence of infection. This study highlights the importance of isolation measures to prevent household transmission of SARS-CoV-2 as well as counters common thought that children are less likely to transmit infection.
METHODS: A cross-sectional study was conducted on households with children and a recent SARS-CoV-2 infection in Atlanta, GA. Participants were enrolled from December 2020 through November 2021. Salivary IgG against SARS-CoV-2 spike and nucleocapsid antigens was measured and household and infection data collected and analysed.
RESULTS: 49 households participated, including 121 adults and 57 children with 118 (66%) individuals having been infected with SARS-CoV-2. Mean SARS-CoV-2 secondary infection rate was 0.55 (95% CI 0.41 to 0.69) and median, 0.67 (range 0-1.0). Incidence rate did not differ significantly between households with paediatric versus adult index cases (incidence rate ratio (IRR) 0.97, 95% CI 0.63 to 1.49). However, sharing a bedroom or bathroom was associated with a higher incidence of secondary infection (IRR 2.36, 95% CI 1.49 to 3.74). Neighbourhood deprivation index was associated with higher household SARS-CoV-2 incidence, but this did not reach statistical significance.
CONCLUSIONS: Child index cases appeared as likely to result in household secondary SARS-CoV-2 infections as adult index cases, while sharing rooms was associated with higher incidence of infection. This study highlights the importance of isolation measures to prevent household transmission of SARS-CoV-2 as well as counters common thought that children are less likely to transmit infection.