Computational fluid dynamics analysis of hemodynamic characteristics in aortic dissection induced by intramural hematoma.

In this study, two case models of intramural hematoma (IMH) progressing to aortic dissection were analyzed using computational fluid dynamics, with a focus on the hemodynamic characteristics before and after the dissection. In the initial IMH model, disturbed flows were observed during the early and late phases of contraction within the aortic arch and regions of significant vascular curvature. Furthermore, the IMH models also revealed extensive areas of low time-averaged wall shear stress (TAWSS), high oscillatory shear index (OSI), and high endothelial cell activation potential (ECAP) values, particularly on the lesser-curvature side of the aortic arch. Regions with low TAWSS, high OSI, and high ECAP in IMH cases can be identified as potential high-risk areas for disease progression to aortic dissection.