Epilepsy & behavior : E&B · 2025
Epilepsy and migraine: A bidirectional mendelian randomization study.
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Chen Fangliang, Sun Jianyun, Lei Jianxiang, Wang Yu
Аннотация
OBJECTIVE: Numerous observational research reports have consistently demonstrated a significant association between migraines and epilepsy, but it remains uncertain whether a causal relationship exists between these two diseases. This study aims to explore the potential causal relationship between epilepsy and migraine through a two-sample bidirectional Mendelian randomization (MR) analysis.
METHODS: A two-sample bidirectional MR analysis was conducted using the data from the genome-wide association studies (GWAS) of epilepsy and migraine in the European population. The primary analytical approach was the inverse variance weighted (IVW) method, with additional MR methods, including MR-Egger and weighted median, employed for complementary analysis. Comprehensive sensitivity analyses were also performed to assess the robustness of the results.
RESULTS: The MR analysis showed no evidence of a causal relationship between epilepsy and migraine (P > 0.05) in either the forward or reverse analysis. Sensitivity analyses validated the reliability of the results.
SIGNIFICANCE: No evidence of a genetic causal relationship between migraine and epilepsy was identified. However, the mechanisms underlying the observed association between the two diseases in observational studies warrant further investigation.
METHODS: A two-sample bidirectional MR analysis was conducted using the data from the genome-wide association studies (GWAS) of epilepsy and migraine in the European population. The primary analytical approach was the inverse variance weighted (IVW) method, with additional MR methods, including MR-Egger and weighted median, employed for complementary analysis. Comprehensive sensitivity analyses were also performed to assess the robustness of the results.
RESULTS: The MR analysis showed no evidence of a causal relationship between epilepsy and migraine (P > 0.05) in either the forward or reverse analysis. Sensitivity analyses validated the reliability of the results.
SIGNIFICANCE: No evidence of a genetic causal relationship between migraine and epilepsy was identified. However, the mechanisms underlying the observed association between the two diseases in observational studies warrant further investigation.