Journal of autoimmunity · 2025
Histological pattern of non-infectious thoracic aortitis impacts mortality.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Espitia Olivier, Bruneval Patrick, Liozon Eric, Pouchot Jacques, de Boysson Hubert, Gaudric Julien, Chiche Laurent, Achouh Paul, Roussel Jean-Christian, Miranda Sébastien, Mirault Tristan, Redheuil Alban, Serfaty Jean-Michel, Bénichou Antoine, Agard Christian, Guédon Alexis F, Cacoub Patrice, Paraf François, Fouret Pierre-Jean, Toquet Claire, Le Jeune Sylvain, Biard Lucie, Saadoun David, French study group for large vessel vasculitides (GEFA)
Аннотация
BACKGROUND: Non-infectious aortitis encompasses various histological patterns, but their specific cardiovascular outcomes remain unclear.
OBJECTIVE: To evaluate the mortality associated with non-infectious surgical thoracic aortitis.
METHODS: This retrospective multicenter study included patients who underwent thoracic aortic surgery and had histological evidence of aortitis. The study analyzed the characteristics of patients with non-infectious aortitis presenting either a granulomatous/giant cell histological pattern or a lymphoplasmacytic pattern. Factors associated with mortality were identified using multivariate analysis.
RESULTS: Among 5666 patients who underwent thoracic aortic surgery, 197 were found to have non-infectious aortitis with either a granulomatous/giant cell histological pattern (n = 138) or a lymphoplasmacytic pattern (n = 59). The overall standardized mortality rate (SMR) for patients with non-infectious surgical thoracic aortitis was 1.61 (95 % CI: 1.05; 2.39), with 31.5 % of patients dying within 10 years of the initial procedure. After a median follow-up of 3.5 years [IQR: 0.5-6.8] post-surgery, 31 % of deaths were due to aortic dissection or rupture. The 10-year cumulative incidence of death was 40.1 % (95 % CI, 17.7-61.8) for patients with a granulomatous/giant cell pattern and 14.4 % (95 % CI, 2.6-35.6) for those with a lymphoplasmacytic pattern. Granulomatous/giant cell histological pattern (HR 4.71 [vs lymphoplasmacytic pattern]; 95 % CI, 1.37-16.2; p = 0.023) and aortic dissection at diagnosis (HR 6.07 [vs aneurysm]; 95 % CI, 2.89-12.7; p < 0.0001) were independently associated with increased mortality.
CONCLUSION: This multicenter study found that 31.5 % of patients with non-infectious surgical thoracic aortitis are expected to die within 10 years of their initial surgery. The granulomatous/giant cell histological pattern is associated with higher mortality.
OBJECTIVE: To evaluate the mortality associated with non-infectious surgical thoracic aortitis.
METHODS: This retrospective multicenter study included patients who underwent thoracic aortic surgery and had histological evidence of aortitis. The study analyzed the characteristics of patients with non-infectious aortitis presenting either a granulomatous/giant cell histological pattern or a lymphoplasmacytic pattern. Factors associated with mortality were identified using multivariate analysis.
RESULTS: Among 5666 patients who underwent thoracic aortic surgery, 197 were found to have non-infectious aortitis with either a granulomatous/giant cell histological pattern (n = 138) or a lymphoplasmacytic pattern (n = 59). The overall standardized mortality rate (SMR) for patients with non-infectious surgical thoracic aortitis was 1.61 (95 % CI: 1.05; 2.39), with 31.5 % of patients dying within 10 years of the initial procedure. After a median follow-up of 3.5 years [IQR: 0.5-6.8] post-surgery, 31 % of deaths were due to aortic dissection or rupture. The 10-year cumulative incidence of death was 40.1 % (95 % CI, 17.7-61.8) for patients with a granulomatous/giant cell pattern and 14.4 % (95 % CI, 2.6-35.6) for those with a lymphoplasmacytic pattern. Granulomatous/giant cell histological pattern (HR 4.71 [vs lymphoplasmacytic pattern]; 95 % CI, 1.37-16.2; p = 0.023) and aortic dissection at diagnosis (HR 6.07 [vs aneurysm]; 95 % CI, 2.89-12.7; p < 0.0001) were independently associated with increased mortality.
CONCLUSION: This multicenter study found that 31.5 % of patients with non-infectious surgical thoracic aortitis are expected to die within 10 years of their initial surgery. The granulomatous/giant cell histological pattern is associated with higher mortality.