Internal medicine (Tokyo, Japan) · 2005
Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C.
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Sohda Tetsuro, Tomioka Yoshitaka, Inomata Shinjiro, Morita Isamu, Eguchi Koichi, Aoyagi Kunihiko, Watanabe Hiroshi, Nakamura Shotaro, Sakisaka Shotaro
Аннотация
A 45-year-old man was admitted to our hospital because of chronic hepatitis C and a large liver tumor accompanied by increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), the tumor markers for hepatocellular carcinoma. Endoscopic examination revealed advanced gastric cancer. Biopsy specimens of the stomach and liver showed gastric adenocarcinoma and its metastasis to the liver. Immunohistochemical studies demonstrated that adenocarcinoma cells both of the stomach and liver, were positive for the antibodies against AFP as well as DCP. Expression of AFP mRNA was shown in the cancer cells of the stomach. Accordingly, we diagnosed this patient with AFP- and DCP-producing adenocarcinoma of the stomach together with liver metastasis.
Предметные рубрики MeSH
AdenocarcinomaBiomarkersBiomarkers, TumorBiopsyDiagnosis, DifferentialFatal OutcomeFollow-Up StudiesGastroscopyGene Expression Regulation, NeoplasticHepatitis C, ChronicHumansLiver NeoplasmsMaleMiddle AgedProtein PrecursorsProthrombinRNA, MessengerStomach NeoplasmsTomography, X-Ray Computedalpha-Fetoproteins