Persistent epithelial defect following photorefractive keratectomy: A case presentation and review of contributing factors.

Photorefractive keratectomy (PRK) is a commonly performed refractive surgery that has pain as one of the most encountered adverse effects postoperatively. Hence, topical nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed post-PRK. While there is conflicting evidence on their impact on delayed epithelialization, this is not a concern if the epithelium heals promptly with standard treatment. However, persistent epithelial defect (PED) is a serious problem that can lead to devastating complications. Here, we report on a patient with Vitamin D deficiency who underwent uneventful PRK. Despite receiving full-standard treatment, the patient developed a PED with no identifiable underlying cause. This case underscores the need to reconsider the routine use of NSAIDs post-PRK and suggests a potential link with Vitamin D deficiency.