Medicine · 2017
Regorafenib-induced retinal and gastrointestinal hemorrhage in a metastatic colorectal cancer patient with liver dysfunction: A case report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Tsuchihashi Kenji, Shimokawa Hozumi, Takayoshi Kotoe, Nio Kenta, Aikawa Tomomi, Matsushita Yuzo, Wada Iori, Arita Shuji, Ariyama Hiroshi, Kusaba Hitoshi, Sonoda Koh-Hei, Akashi Koichi, Baba Eishi
Аннотация
RATIONALE: Regorafenib is effective for metastatic colorectal cancer but its toxicity such as hemorrhage should be considered. The safety of regorafenib for the patient with the liver disease is not known.
PATIENT CONCERNS: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50% dose reduction due to liver dysfunction.
DIAGNOSES: Fundus examination revealed hemorrhage of the retinal vein.
INTERVENTIONS: Regorafenib treatment was discontinued and observational therapy was pursued.
OUTCOMES: Retinal and gastrointestinal hemorrhage resolved in 1 week.
LESSONS: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.
PATIENT CONCERNS: Seventy-one-year old man of colon cancer had myodesopsia and blood stool after 14 days from the initiation of regorafenib administration with 50% dose reduction due to liver dysfunction.
DIAGNOSES: Fundus examination revealed hemorrhage of the retinal vein.
INTERVENTIONS: Regorafenib treatment was discontinued and observational therapy was pursued.
OUTCOMES: Retinal and gastrointestinal hemorrhage resolved in 1 week.
LESSONS: Retinal hemorrhage should be considered as the differential diagnosis of myodesopsia in the patient treated by regorafenib. Safety and pharmacokinetic of continuous regorafenib administration for patients with liver dysfunction remains to be clarified.