Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2009
Contact dermatitis due to use of Octenisept in wound care.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Calow Trevis, Oberle Kristina, Bruckner-Tuderman Leena, Jakob Thilo, Schumann Hauke
Аннотация
BACKGROUND: Octenisept, containing 0.1 % octenidine/2 % phenoxyethanol, is a widely used antiseptic in modern wound management. It is considered to have a very low allergenic potential. Thus far, neither allergic nor irritant contact dermatitis to the product has been described.
PATIENTS AND METHODS: Chronic wounds in 251 patients were treated with Octenisept; 11 developed signs of contact dermatitis. The symptoms improved after discontinuation of the antiseptic. Eight of these patients were patch tested to the antiseptic and its components.
RESULTS: The eight patients all showed a positive reaction to the product. In at least three cases a reaction to the components cocamidopropyl betaine and phenoxyethanol was found, but not to octenidine dihydrochloride.
CONCLUSIONS: In this cohort, more than three percent of the treated patients developed a contact dermatitis to the antiseptic. However, the differentiation between allergic and irritant contact dermatitis towards the ingredients of the antiseptic remains problematic.
PATIENTS AND METHODS: Chronic wounds in 251 patients were treated with Octenisept; 11 developed signs of contact dermatitis. The symptoms improved after discontinuation of the antiseptic. Eight of these patients were patch tested to the antiseptic and its components.
RESULTS: The eight patients all showed a positive reaction to the product. In at least three cases a reaction to the components cocamidopropyl betaine and phenoxyethanol was found, but not to octenidine dihydrochloride.
CONCLUSIONS: In this cohort, more than three percent of the treated patients developed a contact dermatitis to the antiseptic. However, the differentiation between allergic and irritant contact dermatitis towards the ingredients of the antiseptic remains problematic.