Journal of medical primatology · 2026
Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.).
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Fayette Melissa A, Moresco Anneke, Bassiouny Enass, Agnew Dalen W, Petroff Brian
Аннотация
BACKGROUND: Thyroid disease is reported in orangutans, but to properly diagnose and manage these disorders, reference intervals for circulating thyroid hormones are needed.
METHODS: Commercial immunoassay kits for total thyroxine (TT4) and free thyroxine (FT4) were validated for use in orangutans (Pongo spp.). Archived serum (n = 133) was analyzed for TT4, FT4, total triiodothyronine (TT3), and thyroid-stimulating hormone (TSH).
RESULTS: Female orangutans had significantly higher TT4 and TT3 levels compared to males. Adolescent male orangutans had significantly higher FT4 levels compared to adolescent females. Adolescent orangutans had significantly higher TT3 levels compared to adults. Orangutans exhibiting three or more clinical signs consistent with hypothyroidism (n = 8) had significantly higher TSH levels compared to clinically normal orangutans (n = 125) but no significant differences in TT4, FT4, or TT3.
CONCLUSIONS: Age and sex-related variation in circulating thyroid hormone concentrations in orangutans is described. Elevated TSH levels are the most consistent finding in orangutans with clinical signs of hypothyroidism.
METHODS: Commercial immunoassay kits for total thyroxine (TT4) and free thyroxine (FT4) were validated for use in orangutans (Pongo spp.). Archived serum (n = 133) was analyzed for TT4, FT4, total triiodothyronine (TT3), and thyroid-stimulating hormone (TSH).
RESULTS: Female orangutans had significantly higher TT4 and TT3 levels compared to males. Adolescent male orangutans had significantly higher FT4 levels compared to adolescent females. Adolescent orangutans had significantly higher TT3 levels compared to adults. Orangutans exhibiting three or more clinical signs consistent with hypothyroidism (n = 8) had significantly higher TSH levels compared to clinically normal orangutans (n = 125) but no significant differences in TT4, FT4, or TT3.
CONCLUSIONS: Age and sex-related variation in circulating thyroid hormone concentrations in orangutans is described. Elevated TSH levels are the most consistent finding in orangutans with clinical signs of hypothyroidism.