CNS neuroscience & therapeutics · 2025
Effects of Transcranial Pulse Stimulation of the Primary Motor Cortex on Motor Performance in Healthy Adults: A Randomized Crossover Pilot Study.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Qin Penny Ping, Chak Ivan Kin-Yeung, Kan Rebecca Lai-Di, Jin Min-Xia, Zhang Bella Bing-Bing, Xia Adam Wei-Li, Lin Tim Tian-Ze, Wang Sharie Xiao, Liu Jian-Hui, Cheung Teris, Kranz Georg S
Аннотация
AIMS: We aimed to investigate the behavioral aftereffects of a novel noninvasive brain stimulation technique-transcranial pulse stimulation (TPS)-applied over the right motor cortex (rM1) in healthy adults.
METHODS: Thirty-four healthy adults underwent a randomized, subject- and analyst- blind, crossover trial, receiving active TPS over the rM1 or control TPS over the vertex in two sessions 24 h apart. Motor performance was assessed using the Nine-Hole Peg Test (NHPT) and the Simple Reaction Time Task (SRTT) before, immediately after, and every 10 min for 40 min after each session. A linear mixed model and post hoc analyses were applied to evaluate the effects.
RESULTS: No significant interaction effect (stimulation condition × time) was found. The left-hand NHPT performance significantly improved from 10 min post-TPS onward in both conditions (ps ≤ 0.002).
CONCLUSION: A single session of rM1-TPS does not yield significant improvements in motor dexterity compared to vertex-TPS. Future well-powered studies with a sham control condition and multiple stimulation sessions are needed to investigate the aftereffects using a combination of neurophysiological and neuroimaging approaches.
TRIAL REGISTRATION: This study was registered in ClinicalTrial.gov in April 2024 (NCT06312930).
METHODS: Thirty-four healthy adults underwent a randomized, subject- and analyst- blind, crossover trial, receiving active TPS over the rM1 or control TPS over the vertex in two sessions 24 h apart. Motor performance was assessed using the Nine-Hole Peg Test (NHPT) and the Simple Reaction Time Task (SRTT) before, immediately after, and every 10 min for 40 min after each session. A linear mixed model and post hoc analyses were applied to evaluate the effects.
RESULTS: No significant interaction effect (stimulation condition × time) was found. The left-hand NHPT performance significantly improved from 10 min post-TPS onward in both conditions (ps ≤ 0.002).
CONCLUSION: A single session of rM1-TPS does not yield significant improvements in motor dexterity compared to vertex-TPS. Future well-powered studies with a sham control condition and multiple stimulation sessions are needed to investigate the aftereffects using a combination of neurophysiological and neuroimaging approaches.
TRIAL REGISTRATION: This study was registered in ClinicalTrial.gov in April 2024 (NCT06312930).