Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
The effects of transcranial direct current stimulation over the prefrontal cortex on reactive aggressive behavior in healthy volunteers: a systematic review and meta-analysis of randomized controlled trials.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод пока не подготовлен
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Sikembi Pedro Tchicama, Batista Albe Dias, Monteiro Wanessa de Sousa, Medina Pablo Andrés Vega, Yu Leo, de Oliveira Adilson José Manuel, de Amorim Robson Luís Oliveira
Аннотация
OBJECTIVES: The effects of transcranial direct current stimulation over the prefrontal cortex on reactive aggressive behavior are unclear. We conducted an updated systematic review and meta-analysis of randomized controlled trials comparing the effects of anodal transcranial direct current stimulation vs. sham stimulation on reactive aggressive behavior in healthy volunteers experimentally induced to aggressive behavior.
METHODS: We systematically searched the PubMed, Cochrane, Embase, and PsycInfo databases for randomized controlled trials comparing transcranial direct current stimulation to sham stimulation over the prefrontal cortex on reactive aggressive behavior. We computed the standardized mean difference (SMD) with 95%CIs for all statistical models. Heterogeneity was assessed using I² statistics. The statistical analyses were performed in R 4.5.1.
RESULTS: We included nine trials with 547 participants, of whom 272 (49.7%) underwent anodal transcranial direct current stimulation. There was no significant difference between anodal transcranial direct current stimulation and sham stimulation regarding reactive aggressive behavior (SMD -0.24; 95%CI [-0.54 to 0.05]; p = 0.09; I² = 52.4%). However, subgroup analysis showed that the effects of online (SMD -0.41; 95%CI [-0.61 to -0.20]; I² = 0%), and unilateral (SMD -0.44; 95%CI [-63 to -0.25]; I² = 0%) transcranial direct current stimulation differed significantly from sham stimulation.
CONCLUSIONS: While anodal transcranial direct current stimulation had no significant effect on reactive aggressive behavior in healthy volunteers in the overall analysis, the results suggest that online and unilateral tDCS may have an impact. Given the heterogeneity of the studies and outcome measures, further research is needed to confirm these findings and better understand the role of transcranial direct current stimulation in modulating reactive aggressive behavior.
METHODS: We systematically searched the PubMed, Cochrane, Embase, and PsycInfo databases for randomized controlled trials comparing transcranial direct current stimulation to sham stimulation over the prefrontal cortex on reactive aggressive behavior. We computed the standardized mean difference (SMD) with 95%CIs for all statistical models. Heterogeneity was assessed using I² statistics. The statistical analyses were performed in R 4.5.1.
RESULTS: We included nine trials with 547 participants, of whom 272 (49.7%) underwent anodal transcranial direct current stimulation. There was no significant difference between anodal transcranial direct current stimulation and sham stimulation regarding reactive aggressive behavior (SMD -0.24; 95%CI [-0.54 to 0.05]; p = 0.09; I² = 52.4%). However, subgroup analysis showed that the effects of online (SMD -0.41; 95%CI [-0.61 to -0.20]; I² = 0%), and unilateral (SMD -0.44; 95%CI [-63 to -0.25]; I² = 0%) transcranial direct current stimulation differed significantly from sham stimulation.
CONCLUSIONS: While anodal transcranial direct current stimulation had no significant effect on reactive aggressive behavior in healthy volunteers in the overall analysis, the results suggest that online and unilateral tDCS may have an impact. Given the heterogeneity of the studies and outcome measures, further research is needed to confirm these findings and better understand the role of transcranial direct current stimulation in modulating reactive aggressive behavior.