Turkish neurosurgery · 2025
Therapeutic Effects of tDCS on Calcium and Glutamate Excitotoxicity in a Cerebral Ischemia? Reperfusion Rat Model.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Akcay Guven, Demirdogen Filiz, Kotan Dilcan, Gul Tuba, Yilmaz Ali, Ergul Yusuf Muslum, Celik Cagla
Аннотация
AIM: To investigate the therapeutic effects of transcranial direct current stimulation (tDCS) on calcium and glutamate excitotoxicity caused by ischemia?reperfusion (IR).
MATERIAL AND METHODS: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2 < sup > nd < /sup > , 24 < sup > th < /sup > , and 48 < sup > th < /sup > h of IR. The motor and cognitive functions and the concentrations of Ca < sup > 2+ < /sup > , glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated.
RESULTS: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca < sup > 2+ < /sup > , glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group.
CONCLUSION: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca < sup > 2+ < /sup > and glutamate excitotoxicity.
MATERIAL AND METHODS: The IR model was generated by transient middle cerebral artery occlusion. tDCS treatment was applied at 1 mA for 30 min daily at the 2 < sup > nd < /sup > , 24 < sup > th < /sup > , and 48 < sup > th < /sup > h of IR. The motor and cognitive functions and the concentrations of Ca < sup > 2+ < /sup > , glutamate, and N-methyl-D-aspartate receptor (NMDAR) in the hippocampus tissues were evaluated.
RESULTS: Results showed a reduction in motor and cognitive functions in the IR group compared with that in the sham group, whereas these functions increased in the IR+tDCS group compared with those in the IR group. Ca < sup > 2+ < /sup > , glutamate, and NMDAR concentrations were higher in the IR group than in the sham group but lower in the IR+tDCS group than in the IR group.
CONCLUSION: These results suggest that tDCS treatment improves motor and cognitive dysfunctions after IR and exerts therapeutic effects on learning and memory through the regulation of Ca < sup > 2+ < /sup > and glutamate excitotoxicity.