Cerebral amebiasis due to Acanthamoeba sp. in a patient with complete gp91 phox deficiency.

Rare variants in CYBB (encoding gp91 phox ) are responsible for chronic granulomatous disease. We report a patient affected by multiple cerebral abscesses caused by Acanthamoeba sp. and complete gp91 phox deficiency. The respiratory burst evaluation is recommended in any child with a deep abscess.