Haematologica · 2010
Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zibellini Silvia, Capello Daniela, Forconi Francesco, Marcatili Paolo, Rossi Davide, Rattotti Sara, Franceschetti Silvia, Sozzi Elisa, Cencini Emanuele, Marasca Roberto, Baldini Luca, Tucci Alessandra, Bertoni Francesco, Passamonti Francesco, Orlandi Ester, Varettoni Marzia, Merli Michele, Rizzi Silvia, Gattei Valter, Tramontano Anna, Paulli Marco, Gaidano Gianluca, Arcaini Luca
Аннотация
Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) "SMZL-specific subsets" (n=5), composed only of 12 SMZL (9 HCV-from our series); ii) "Non-Hodgkin's lymphoma-like subsets" (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV-unrelated epitopes or an antigenic trigger common to other indolent lymphomas.