Is there evidence that methyl heptine carbonate causes allergic contact dermatitis?

The fragrance material methyl heptine carbonate has been cited as a moderately frequent cause of cosmetics-related allergic contact dermatitis. A review of the literature shows that when the underlying clinical data are analyzed, there is only one published case where a possible causal link to a cosmetic product has been established. Predictive tests in a computational model, in animal systems, and in volunteers have demonstrated a significant sensitization potential for this substance but reports of clinical cases of allergy are rare with no new reports appearing in the last two decades. The infrequence of reported cases of allergy may be linked to risk management procedures put in place by the International Fragrance Association (IFRA) more than 20 years ago.