Journal of diabetes and its complications · 2024
Association of detectable C-peptide levels with glycemic control and chronic complications in individuals with type 1 diabetes mellitus: A systematic review and meta-analysis.
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Alan Mahin Seifi, Tayebi Amirhossein, Afshar Elmira Jafari, Alan Sanaz Seifi, Alan Mahnaz Seifi, Fazeli Ramina, Sohbatzade Tooba, Samimisedeh Parham, Rastad Hadith
Аннотация
AIMS: Multiple studies have addressed the association between detectable levels of C-peptide and glycemic control, as well as the development of chronic complications of type 1 diabetes mellitus (T1DM), including both macrovascular and microvascular diseases. We aimed to summarize the available evidence on the clinical significance of detectable levels of C-peptide in T1DM.
METHOD: A systematic search was performed on online databases using the following key terms: T1DM, C-peptide, diabetes mellitus complications, and glycemic parameters. We pooled standardized mean difference (SMD) and odds ratios (OR).
RESULTS: Of the 1519 articles retrieved from the initial search, 38 (12 cohort and 26 cross-sectional studies) met our eligibility criteria. Individuals with T1DM in the detectable C-peptide group, compared with the undetectable C-peptide group, had lower mean HbA1c [pooled SMD (95 % confidence interval (95 % CI)): -0.08 (-0.13 to -0.02), I2 = 0 %, p.
VALUE: 0.005] and daily insulin dose [-0.41 (-0.65 to -0.18), I2 = 83 %, p.value < 0.001]. They also showed lower odds for retinopathy [pooled crude OR (95 % CI): 0.53 (0.41 to 0.69), I2 = 65 %, p.value < 0.001] and nephropathy complications [0.62 (0.55 to 0.70), I2 = 19 %, p.value < 0.001]; however, the two groups were similar regarding neuropathy [0.92 (0.65 to 1.31), I2 = 0 %, p.
VALUE: 0.31].
CONCLUSIONS: The available evidence suggests that individuals with T1DM in the detectable C-peptide group may experience better clinical outcomes.
METHOD: A systematic search was performed on online databases using the following key terms: T1DM, C-peptide, diabetes mellitus complications, and glycemic parameters. We pooled standardized mean difference (SMD) and odds ratios (OR).
RESULTS: Of the 1519 articles retrieved from the initial search, 38 (12 cohort and 26 cross-sectional studies) met our eligibility criteria. Individuals with T1DM in the detectable C-peptide group, compared with the undetectable C-peptide group, had lower mean HbA1c [pooled SMD (95 % confidence interval (95 % CI)): -0.08 (-0.13 to -0.02), I2 = 0 %, p.
VALUE: 0.005] and daily insulin dose [-0.41 (-0.65 to -0.18), I2 = 83 %, p.value < 0.001]. They also showed lower odds for retinopathy [pooled crude OR (95 % CI): 0.53 (0.41 to 0.69), I2 = 65 %, p.value < 0.001] and nephropathy complications [0.62 (0.55 to 0.70), I2 = 19 %, p.value < 0.001]; however, the two groups were similar regarding neuropathy [0.92 (0.65 to 1.31), I2 = 0 %, p.
VALUE: 0.31].
CONCLUSIONS: The available evidence suggests that individuals with T1DM in the detectable C-peptide group may experience better clinical outcomes.