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Войти в исследования Prevalence of transmitted antiretroviral resistance and distribution of HIV-1 subtypes among patients with recent infection in Catalonia (Spain) between 2003 and 2005.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Romero Anabel, Sued Omar, Puig Teresa, Esteve Anna, Pumarola Tomàs, Casabona Jordi, González Victoria, Matas Lurdes, Tural Cristina, Rodrigo Isabel, Margall Núria, Domingo Pere, Casanova Aurora, Ferrer Elena, Caballero Estrella, Ribera Esteve, Farré Joan, Puig Teresa, Amengual M José, Navarro Gemma, Prat Josep M, Masabeu Angels, Simó Josep M, Villaverde Carlos A, Barrufet Pilar, Sauca M Goretti, Ortin Xavier, Ortí Amat, Navarro Rosa, Euras Josep M, Vilaró Josep, Villà M Carme, Montull Santiago, Vilanova Conrad, Pujol Ferran, Díaz Olga, Miró Jose M, AERI study Group
Аннотация
METHODS: After application of the Serological Testing Algorithm for Recent HIV Seroconversion (STARHS), residual aliquots of serum samples from recently infected antiretroviral-naïve individuals were genotyped. FASTA sequences were analyzed using the HIVDB Program. The World Health Organization 2009 List of Mutations for Surveillance of Transmitted HIV-1 Drug Resistant HIV Strains was used to estimate the prevalence of TDR.
RESULTS: Of 182 recently infected patients, 14 (7.7%) presented TDR. Seven (3.8%) had genotypic evidence of TDR against non-nucleoside reverse transcriptase inhibitors, 6 (3.3%) against nucleoside reverse transcriptase inhibitors, 3 (1.6%) against protease inhibitors (PIs), and only 2 individuals (1.1%) presented TDR against more than one class of drugs. Thirty-five (19.2%) patients were infected with a non-B HIV-1 subtype.
CONCLUSION: This is the first study to estimate the prevalence of TDR in recently infected patients in Catalonia. The results are similar to those of studies performed in other Spanish regions. Correct monitoring of these parameters requires systematic epidemiologic surveillance of transmitted resistance.