Second home blood pressure measurements per occasion predict incident cardiovascular events in type 2 diabetes: KAMOGAWA-HBP study.

Home blood pressure (HBP) monitoring is a better prognostic predictor than clinical BP monitoring. However, the suggested number of HBP measurements in each occasion varies across guidelines. The study aimed to identify which HBP measurements in each occasion are more closely associated with new cardiovascular events in patients with type 2 diabetes. This retrospective cohort study included 1082 patients with type 2 diabetes without a history of macrovascular complications. HBP was measured three times each morning and evening for 14 days, and the average value over the 14 days was calculated. During a median follow-up of 7.0 years, 117 patients (11.1%) had cardiovascular events. The Cox proportional hazards model was used to examine the association between the average morning home systolic BP (MHSBP) for the 1st, 2nd, and 3rd measurements and cardiovascular events. The adjusted hazard ratios (HR) (95% confidence interval) for the onset of cardiovascular events in the 2nd and 3rd mean MHSBP were 1.129 (1.008-1.265) and 1.135 (1.010-1.275), respectively. The area under the receiver-operating characteristic curve (AUC) for the 2nd, 1st/2nd, 2nd/3rd, and 1st/2nd/3rd mean MHSBP was significantly greater than that of the 1st mean MHSBP (p = 0.040, p = 0.014, p = 0.020, and p = 0.021, respectively). No significant difference was observed between the AUC of the 2nd/3rd and 1st/2nd/3rd mean MHSBP and that of the 1st/2nd mean MHSBP. We recommend that HBP measurements be taken just twice per occasion to predict cardiovascular events in patients with type 2 diabetes.