Indian journal of dermatology · 2023
A Case-Control Study of Serum and Tissue Catalase among Morphological Variants of Vitiligo.
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Periasamy Nandhini, Ramesh V, Matlani Monika
Аннотация
BACKGROUND: Role of oxidative stress in the pathogenesis of vitiligo.
AIM: Estimation of serum and tissue catalase levels in morphological variants of vitiligo.
SETTINGS AND DESIGN: A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital.
MATERIALS AND METHODS: We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls.
STATISTICAL ANALYSIS: The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov-Smirnov test.
RESULTS: Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels.
CONCLUSION: Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations.
AIM: Estimation of serum and tissue catalase levels in morphological variants of vitiligo.
SETTINGS AND DESIGN: A prospective case-control study was conducted in the outpatient department of Dermatology in Safdarjung hospital.
MATERIALS AND METHODS: We estimated levels of serum and tissue catalase in 30 vitiligo patients and 30 matched healthy controls.
STATISTICAL ANALYSIS: The data analysis was done in Statistical Package for Social Sciences (SPSS) version 21.0. Normality of data was tested by Kolmogorov-Smirnov test.
RESULTS: Serum and tissue catalase was lower in vitiligo patients than controls. Serum catalase was lowest in vulgaris type, whereas in the acrofacial type had lowest tissue catalase levels.
CONCLUSION: Vitiligo patients have a generalized oxidative stress functioning at a higher pace as seen with decreased serum and tissue CAT which can well be taken as a marker of active disease and they can be helped with topical pseudoCAT preparations.