The Journal of clinical and aesthetic dermatology · 2023
Granzyme B Gene Polymorphisms Are Associated With Severe Non-segmental Vitiligo.
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El-Taweel Abd El-Aziz, Abdelrahman Amira, Hegazy Hebatallah, Salem Rehab
Аннотация
BACKGROUND: Granzyme B (GZMB) gene is related to human immunity and is considered as one of the genes indulged in vitiligo.
OBJECTIVE: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.
METHODS: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction.
RESULTS: P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores.
CONCLUSION: GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.
OBJECTIVE: To evaluate the association between GZMB (R55Q) and (P94Q) gene polymorphisms with vitiligo development in a sample of vitiligo Egyptian patients.
METHODS: This study was a case-control study which included 100 non-segmental vitiligo patients as well as a control group consisted of 100 healthy, sex and age matched vitiligo free individuals. The polymorphism of GZMB gene at (R55Q) and (P94A) were analyzed by polymerase chain reaction.
RESULTS: P94Q and R55Q gene polymorphisms were significantly associated with higher VASI scores.
CONCLUSION: GZMB (Q55R) and P94A) gene polymorphisms are associated with the susceptibility to develop vitiligo in the Egyptian population and could help predicting more extensive forms of the disease.