[Effects of argon laser irradiation of the iris on the concentration of aqueous prostaglandins and cyclic AMP].

In order to elucidate the influence of acute ocular inflammation on the aqueous humor dynamics and intraocular pressure (IOP), we carried out argon laser photo-coagulations on the rabbit irises and determined the concentrations of aqueous humor prostaglandins (PGs), cyclic AMP and protein. The IOP changed in a biphasic manner, i.e. initial hypertension and later hypotension. The concentrations of aqueous humor PG E2, PG F2 alpha and protein increased markedly after laser irradiation and then decreased gradually, although the concentrations of PG E2 and protein remained significantly higher than the baseline values at 24 hours after the irradiations. The concentrations of aqueous cyclic AMP of the irradiated eyes and control eyes were 67.8 pmol/ml and 29.3 pmol/ml, respectively. We presumed that the increase in concentration of aqueous cyclic AMP and breakdown of the blood-aqueous barrier by PGs caused the reactive hypotension.