Revista medica de Chile · 1993
[Correlation between serum globulin levels and hepatitis C virus antibody].
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Poniachik J, Velasco M, Hurtado C, Brahm J, Chesta J, Sepúlveda C
Аннотация
BACKGROUND: some studies have suggested that the elevation of serum globulins in patients with chronic autoimmune hepatitis, paraproteinemias and rheumatoid arthritis could affect the determination of false positive hepatitis C virus antibodies (anti-HCV).
AIM: to study the relationship between positive anti-HCV and serum levels of globulins in patients with liver disease.
PATIENTS AND METHODS: one hundred thirty one patients with liver disease, 49 alcoholic, 38 cryptogenetic, 17 autoimmune and 27 with other causes, were studies prospectively measuring simultaneously anti-HCV and serum levels of total, gamma and immuno-globulins (IgA, IgG and IgM). These levels were compared between anti-HCV positive and negative groups and correlated with the ratio between serum optical density/cutoff optical density of the anti HCV assay.
RESULTS: Twenty eight patients (21.3%) were anti-HCV positive, no differences in serum globulins between these patients and anti-HCV negative patients and no correlations between serum globulins and anti-HCV optical densities were observed.
CONCLUSIONS: the hypergamma-globulinemia observed in these patients with liver diseases would not be responsible for positive hepatitis C virus antibodies.
AIM: to study the relationship between positive anti-HCV and serum levels of globulins in patients with liver disease.
PATIENTS AND METHODS: one hundred thirty one patients with liver disease, 49 alcoholic, 38 cryptogenetic, 17 autoimmune and 27 with other causes, were studies prospectively measuring simultaneously anti-HCV and serum levels of total, gamma and immuno-globulins (IgA, IgG and IgM). These levels were compared between anti-HCV positive and negative groups and correlated with the ratio between serum optical density/cutoff optical density of the anti HCV assay.
RESULTS: Twenty eight patients (21.3%) were anti-HCV positive, no differences in serum globulins between these patients and anti-HCV negative patients and no correlations between serum globulins and anti-HCV optical densities were observed.
CONCLUSIONS: the hypergamma-globulinemia observed in these patients with liver diseases would not be responsible for positive hepatitis C virus antibodies.