Atherosclerosis · 2025
Long-term trends in cardiovascular risk factors and cardiovascular risk following bariatric surgery: A 10-year prospective cohort study.
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Humięcka Maria, Sawicka Ada, Kędzierska Kinga, Kotowicz Michał, Koczkodaj Maria, Jaworski Paweł, Binda Artur, Tarnowski Wiesław, Jankowski Piotr
Аннотация
BACKGROUND AND AIMS: Bariatric surgery (BS) leads to a durable weight loss and remission of diabetes, but the long-term impact on hypertension and lipid disorders is not unequivocal. The aim of the study was to assess the impact of BS on the level of cardiovascular (CV) risk factors and estimate CV risk 10 years following BS.
METHODS: The study included patients who underwent BS in 2010-2015, re-evaluated in 2023-2024. The CV risk was estimated using the Pooled Cohort Equations calculator.
RESULTS: The analysis included 188 patients (76 % women), with a mean age of 43.3 ± 9.8 years, who underwent sleeve gastrectomy (73.4 %) and gastric bypass (26.6 %). The observation period lasted 10 (9-11) years, and BMI decreased from 41.7 (38.2-46.0) kg/m2 to 33.9 (29.4-38.8) kg/m2 (p < 0.001). The prevalence of hypertension decreased from 76.6 % to 67.0 % (p < 0.05), while the prevalence of diabetes (31.9 % vs. 23.9 %; p = 0.08), hypercholesterolemia (77.1 % vs. 70.7 %; p = 0.16), and smoking (from 35.6 % to 31.4 %; p = 0.39) did not change significantly. CV risk increased from 1.6 % (0.6-4.2 %) to 2.6 % (1.0-6.7 %) (p < 0.001). Since patients examined during the follow-up examination were 10 years older and since age is a main driver of CV risk, we also calculated CV risk using the baseline age, which was significantly lower, 1.1 % (0.4-3.0 %; p < 0.001 vs baseline).
CONCLUSIONS: Long-term weight reduction following BS is related to the decrease in the estimated CV risk.
METHODS: The study included patients who underwent BS in 2010-2015, re-evaluated in 2023-2024. The CV risk was estimated using the Pooled Cohort Equations calculator.
RESULTS: The analysis included 188 patients (76 % women), with a mean age of 43.3 ± 9.8 years, who underwent sleeve gastrectomy (73.4 %) and gastric bypass (26.6 %). The observation period lasted 10 (9-11) years, and BMI decreased from 41.7 (38.2-46.0) kg/m2 to 33.9 (29.4-38.8) kg/m2 (p < 0.001). The prevalence of hypertension decreased from 76.6 % to 67.0 % (p < 0.05), while the prevalence of diabetes (31.9 % vs. 23.9 %; p = 0.08), hypercholesterolemia (77.1 % vs. 70.7 %; p = 0.16), and smoking (from 35.6 % to 31.4 %; p = 0.39) did not change significantly. CV risk increased from 1.6 % (0.6-4.2 %) to 2.6 % (1.0-6.7 %) (p < 0.001). Since patients examined during the follow-up examination were 10 years older and since age is a main driver of CV risk, we also calculated CV risk using the baseline age, which was significantly lower, 1.1 % (0.4-3.0 %; p < 0.001 vs baseline).
CONCLUSIONS: Long-term weight reduction following BS is related to the decrease in the estimated CV risk.