Annals of hematology · 2024
Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut.
Наблюдательное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Vegas Villalmanzo Blanca, Cantera Estefanía Rodrigo, Muñoz Madrid Sara, Cerrato Salas Mariana, Arnaiz Martín Irene, Molina Pérez Marta, Sagrista López Beatriz, Ruiz Ramírez Yolanda, Cucharero Martín Javier, Estival Monteliú Pablo, Ropero Gradilla Paloma, Ferrer Benito Sara, Martín Hernández María Paz, González Fernández Fernando Ataulfo, Gómez Álvarez Miguel, Villegas Martínez Ana, Benavente Cuesta Celina, Martínez Nieto Jorge
Аннотация
It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (p<0.001) and ≥ 3 points in the TMA mortality score (p<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.