Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders.
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Ringelstein Marius, Harmel Jens, Zimmermann Hanna, Brandt Alexander U, Paul Friedemann, Haarmann Axel, Buttmann Mathias, Hümmert Martin W, Trebst Corinna, Schroeder Christoph, Ayzenberg Ilya, Kleiter Ingo, Hellwig Kerstin, Havla Joachim, Kümpfel Tania, Jarius Sven, Wildemann Brigitte, Rommer Paulus, Weber Martin S, Pellkofer Hannah, Röpke Luise, Geis Christian, Retzlaff Nele, Zettl Uwe, Deppe Michael, Klotz Luisa, Young Kim, Stellmann Jan-Patrick, Kaste Matthias, Kermer Pawel, Marouf Wael, Lauda Florian, Tumani Hayrettin, Graf Jonas, Klistorner Alexander, Hartung Hans-Peter, Aktas Orhan, Albrecht Philipp, Neuromyelitis Optica Study Group (NEMOS)
Аннотация
METHODS: A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models.
RESULTS: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively.
CONCLUSION: This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.