International journal of dermatology · 2009
Marked elevation of serum macrophage migration inhibitory factor levels in patients with pemphigus vulgaris.
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Namazi Mohammad Reza, Fallahzadeh Mohammad Kazem, Shaghelani Hassan, Kamali-Sarvestani Eskandar
Аннотация
BACKGROUND: There is ample evidence for involvement of macrophage migration inhibitory factor (MIF) in autoimmune and inflammatory diseases.
OBJECTIVE: The aim of this study was to determine whether MIF levels were raised in the sera of patients with pemphigus vulgaris (PV).
METHODS: Serum MIF levels were measured using ELISA method in 22 patients with active PV and 21 age- and sex-matched healthy controls and the results were compared with each other.
RESULTS: The mean serum MIF levels was significantly higher in PV patients than in control subjects (11.99 +/- 1.63 pg/m vs. 1.83 +/- 0.22 pg/ml; P-value = 0.0001).
CONCLUSIONS: Elevated MIF levels in the sera of PV patients could participate in disease induction by activation of T cells as well as induction of autoantibody production by B cells. Given that MIF counter-regulates the effects of steroids, MIF antagonists may prove to be very effective, novel steroid-sparing agents for this life-threatening conundrum.
OBJECTIVE: The aim of this study was to determine whether MIF levels were raised in the sera of patients with pemphigus vulgaris (PV).
METHODS: Serum MIF levels were measured using ELISA method in 22 patients with active PV and 21 age- and sex-matched healthy controls and the results were compared with each other.
RESULTS: The mean serum MIF levels was significantly higher in PV patients than in control subjects (11.99 +/- 1.63 pg/m vs. 1.83 +/- 0.22 pg/ml; P-value = 0.0001).
CONCLUSIONS: Elevated MIF levels in the sera of PV patients could participate in disease induction by activation of T cells as well as induction of autoantibody production by B cells. Given that MIF counter-regulates the effects of steroids, MIF antagonists may prove to be very effective, novel steroid-sparing agents for this life-threatening conundrum.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkersBiopsy, NeedleCase-Control StudiesDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPemphigusProbabilitySensitivity and SpecificitySeverity of Illness IndexStatistics, NonparametricYoung Adult