Recompensation after transjugular intrahepatic portosystemic shunt reduces mortality risk: A long-term follow-up study.

OBJECTIVE

This study aims to analyze the occurrence of recompensation after transjugular intrahepatic portosystemic shunt (TIPS) for patients with cirrhosis and portal hypertension and its impact on mortality risk.

METHODS

The clinical data of 621 cirrhotic patients who underwent TIPS creation were retrospectively analyzed. Patients were categorized into a recompensation group (n = 126) and a non-recompensation group (n = 495). Binary logistic regression was used to identify independent predictors of recompensation. Kaplan-Meier (KM) survival curves were employed to assess the differences in survival between the two groups, and the Cox proportional hazards model was utilized to analyze the risk factors for mortality.

RESULTS

At 12 months after TIPS placement, 20.3 % of patients achieved recompensation. The recompensation group demonstrated significant improvements in both Child-Pugh and MELD scores (P < 0.05). Sarcopenia and platelet count (PLT) were identified as independent predictors of recompensation. The cumulative survival rate in the recompensation group was significantly higher than that of the non-recompensation group (HR = 2.275, 95 % CI = 1.606-3.223, Log-rank P < 0.001). Age, sarcopenia, and the occurrence of recompensation were identified as independent factors that influenced mortality risk.

CONCLUSION

TIPS was associated with recompensation in certain patients, and the occurrence of recompensation is significantly associated with improved long-term survival.