Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses · 2025
Comparison of Sedation Efficacy Between Propofol-ketamine and Propofol-fentanyl Combinations in Short Gynecological Procedures.
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Tamdogan Ilke, Degermenci Mehmet, Olgun Keles Bilge, Tutar Mahmut Sami
Аннотация
PURPOSE: This study aimed to compare the sedoanalgesic efficacy and side effects between propofol-ketamine and propofol-fentanyl combinations in short gynecological procedures for increasing surgical analgesia and improving patient comfort.
DESIGN: This was a randomized (1:1), double-blind, prospective trial.
METHODS: This randomized, double-blind controlled trial included patients who underwent short gynecological procedures lasting less than 30 minutes. Group K (n = 30) received 0.5 mg/kg ketamine and 1 mg/kg propofol, whereas group F (n = 30) received 1 mcg/kg fentanyl and 1 mg/kg propofol. The sedation levels, hemodynamic changes, adverse events, and both surgical and patient satisfaction were evaluated.
FINDINGS: Lower extremity movement was more frequently observed in group F (P = .020), but surgical satisfaction was higher in group K (P < .001). Both groups exhibited similar sedation, surgical time, and patient satisfaction scores. However, group F had shorter recovery times and exhibited more frequent apnea and desaturation. Furthermore, postoperative dizziness was more common in this group (P = .003).
CONCLUSIONS: Both drug combinations provide safe anesthesia with stable hemodynamics and fewer side effects. The use of propofol-ketamine resulted in fewer lower extremity movements, leading to greater surgical satisfaction.
DESIGN: This was a randomized (1:1), double-blind, prospective trial.
METHODS: This randomized, double-blind controlled trial included patients who underwent short gynecological procedures lasting less than 30 minutes. Group K (n = 30) received 0.5 mg/kg ketamine and 1 mg/kg propofol, whereas group F (n = 30) received 1 mcg/kg fentanyl and 1 mg/kg propofol. The sedation levels, hemodynamic changes, adverse events, and both surgical and patient satisfaction were evaluated.
FINDINGS: Lower extremity movement was more frequently observed in group F (P = .020), but surgical satisfaction was higher in group K (P < .001). Both groups exhibited similar sedation, surgical time, and patient satisfaction scores. However, group F had shorter recovery times and exhibited more frequent apnea and desaturation. Furthermore, postoperative dizziness was more common in this group (P = .003).
CONCLUSIONS: Both drug combinations provide safe anesthesia with stable hemodynamics and fewer side effects. The use of propofol-ketamine resulted in fewer lower extremity movements, leading to greater surgical satisfaction.