Role of Antipsychotic Agents for Adjunct Sedation.

Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality evidence from RCTs is not yet available to guide the use of these agents as adjunct sedatives in the intensive care unit. The purpose of this article is to explore the role of antipsychotics as adjunctive sedatives in mechanically ventilated adults receiving continuous sedation.