Histology and histopathology · 1995
Hepatocyte-like cells in the pancreatic islets: study of the human foetal pancreas and experimental models.
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Tsanadis G, Kotoulas O, Lollis D
Аннотация
OBJECTIVE: To determine the existence of hepatocyte-like cells in the human foetal pancreas.
STUDY DESIGN: Foetal pancreas was examined in parallel with two experimental models involving pancreatic tissue regeneration. Foetal pancreases (n = 20; 10 to 18 weeks) were obtained from spontaneous abortions and were histologically examined using haematoxylin-eosin and PAS staining. Tissues from food-deprived and copper-deficient female Wistar rats were studied following D-penicillamine administration, and tissue from female hamsters was evaluated following administration of a pancreatic carcinogen. Histological examination in animal studies included haematoxylin-eosin staining, and diaminobenzidine histochemistry.
RESULTS: The presence of a characteristic cell-type whose morphology was distinct from islets cells and exocrine pancreas cells was observed in human foetal pancreatic islets. These cells were morphologically similar to hepatocyte-like cells and were compatible to those observed in the experimental models. Topographical relationships suggest that these originate from stem cells which are related to the pancreas duct cells.
CONCLUSION: We conclude that hepatocyte-like cells or precursors exist in the human foetal pancreas.
STUDY DESIGN: Foetal pancreas was examined in parallel with two experimental models involving pancreatic tissue regeneration. Foetal pancreases (n = 20; 10 to 18 weeks) were obtained from spontaneous abortions and were histologically examined using haematoxylin-eosin and PAS staining. Tissues from food-deprived and copper-deficient female Wistar rats were studied following D-penicillamine administration, and tissue from female hamsters was evaluated following administration of a pancreatic carcinogen. Histological examination in animal studies included haematoxylin-eosin staining, and diaminobenzidine histochemistry.
RESULTS: The presence of a characteristic cell-type whose morphology was distinct from islets cells and exocrine pancreas cells was observed in human foetal pancreatic islets. These cells were morphologically similar to hepatocyte-like cells and were compatible to those observed in the experimental models. Topographical relationships suggest that these originate from stem cells which are related to the pancreas duct cells.
CONCLUSION: We conclude that hepatocyte-like cells or precursors exist in the human foetal pancreas.