The American journal of psychiatry · 2008
Amygdala volume associated with alcohol abuse relapse and craving.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wrase Jana, Makris Nicos, Braus Dieter F, Mann Karl, Smolka Michael N, Kennedy David N, Caviness Verne S, Hodge Steven M, Tang Lena, Albaugh Matthew, Ziegler David A, Davis Orin C, Kissling Christian, Schumann Gunter, Breiter Hans C, Heinz Andreas
Аннотация
OBJECTIVE: Amygdala volume has been associated with drug craving in cocaine addicts, and amygdala volume reduction is observed in some alcohol-dependent subjects. This study sought an association in alcohol-dependent subjects between volumes of reward-related brain regions, alcohol craving, and the risk of relapse.
METHOD: Besides alcohol craving, the authors assessed amygdala, hippocampus, and ventral striatum volumes in 51 alcohol-dependent subjects and 52 age- and education-matched healthy comparison subjects after detoxification. After imaging and clinical assessment, patients were followed for 6 months and alcohol intake was recorded.
RESULTS: Alcohol-dependent subjects showed reduced amygdala, hippocampus, and ventral striatum volumes and reported stronger craving in relation to healthy comparison subjects. However, only amygdala volume and craving differentiated between subsequent relapsers and abstainers. A significant decrease of amygdala volume in alcohol-dependent subjects was associated with increased alcohol craving before imaging and an increased alcohol intake during the 6-month follow-up period.
CONCLUSIONS: These findings suggest a relationship between amygdala volume reduction, alcohol craving, and prospective relapse into alcohol consumption.
METHOD: Besides alcohol craving, the authors assessed amygdala, hippocampus, and ventral striatum volumes in 51 alcohol-dependent subjects and 52 age- and education-matched healthy comparison subjects after detoxification. After imaging and clinical assessment, patients were followed for 6 months and alcohol intake was recorded.
RESULTS: Alcohol-dependent subjects showed reduced amygdala, hippocampus, and ventral striatum volumes and reported stronger craving in relation to healthy comparison subjects. However, only amygdala volume and craving differentiated between subsequent relapsers and abstainers. A significant decrease of amygdala volume in alcohol-dependent subjects was associated with increased alcohol craving before imaging and an increased alcohol intake during the 6-month follow-up period.
CONCLUSIONS: These findings suggest a relationship between amygdala volume reduction, alcohol craving, and prospective relapse into alcohol consumption.
Предметные рубрики MeSH
AdultAlcoholismAmygdalaCorpus StriatumDiagnostic and Statistical Manual of Mental DisordersDisruptive, Impulse Control, and Conduct DisordersFemaleHippocampusHumansInternational Classification of DiseasesMagnetic Resonance ImagingMaleMiddle AgedPersonality DisordersPrevalenceRecurrenceSeverity of Illness Index