Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats.

The effect of transient inactivation of the amygdala on expression of cocaine conditioned place preference (CPP) and locomotion was studied. We found that rats with bilateral but not unilateral amygdala cannula placement exhibited increased CPP expression during a vehicle and a cocaine test as well as increased cocaine-induced hyper-locomotion. We discuss the observed effects as being caused by the cannulation per se and we conclude that the applied cannulation produced an increased responsiveness of the amygdala by a yet undetermined mechanism.