Clinical toxicology (Philadelphia, Pa.) · 2026
Three cases of wood-lover paralysis: clinical insights from Victoria, Australia.
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Silvester Annie, Hampton Sarah, May Tom W, Holmes Gareth D, Leang Yit Hung
Аннотация
INTRODUCTION: Wood-lover paralysis is a rare complication of Psilocybe mushroom ingestion. The clinical spectrum is poorly characterized and published cases remain limited.
CASE PRESENTATIONS: We describe three patients who developed acute muscle weakness following ingestion of Psilocybe mushrooms in Victoria, Australia. Written informed consent was obtained from these patients for publication of this case series.
• CASE 1: Mild generalized weakness affecting gait, without other end-organ involvement.
• CASE 2: Severe generalized weakness involving upper and lower limbs, associated with takotsubo cardiomyopathy.
• CASE 3: Severe generalized weakness with respiratory failure, requiring intubation.All patients had a clear temporal relationship between mushroom ingestion and symptom onset. Mushroom samples from Cases 2 and Case 3 were identified as Psilocybe subaeruginosa based on DNA sequence data. Serum toxicology detected psilocin in Case 1 and Case 3.
DISCUSSION: Our findings support a causal role for Psilocybe subaeruginosa; however, no specific alkaloid has yet been proven to cause wood-lover paralysis.
CONCLUSION: These cases highlight the variable severity of wood-lover paralysis, ranging from mild weakness to life-threatening respiratory compromise, and add significantly to the current body of literature on this topic.
CASE PRESENTATIONS: We describe three patients who developed acute muscle weakness following ingestion of Psilocybe mushrooms in Victoria, Australia. Written informed consent was obtained from these patients for publication of this case series.
• CASE 1: Mild generalized weakness affecting gait, without other end-organ involvement.
• CASE 2: Severe generalized weakness involving upper and lower limbs, associated with takotsubo cardiomyopathy.
• CASE 3: Severe generalized weakness with respiratory failure, requiring intubation.All patients had a clear temporal relationship between mushroom ingestion and symptom onset. Mushroom samples from Cases 2 and Case 3 were identified as Psilocybe subaeruginosa based on DNA sequence data. Serum toxicology detected psilocin in Case 1 and Case 3.
DISCUSSION: Our findings support a causal role for Psilocybe subaeruginosa; however, no specific alkaloid has yet been proven to cause wood-lover paralysis.
CONCLUSION: These cases highlight the variable severity of wood-lover paralysis, ranging from mild weakness to life-threatening respiratory compromise, and add significantly to the current body of literature on this topic.