Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2025
Immunological role of IL-25 on gut-dwelling helminths.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Amare Gashaw Azanaw, Wondmagegn Yenesew Mihret, Adugna Adane, Abebaw Desalegn, Melkamu Abateneh, Belew Habtamu, Teffera Zigale Hibstu, Getinet Mamaru, Jemal Mohammed, Baylie Temesgen, Asmare Deresse Sinamaw, Yenesew Abebe, Fenta Abebe, Woreket Mesafint, Setegn Abebaw, Malede Birhanu
Аннотация
Interleukin-25 (IL-25) is a crucial cytokine in coordinating type 2 immunity against gut-dwelling helminths. IL-25 is produced by a variety of cells, including epithelial and immune cells, and primarily stimulates Th2-type immune responses characterized by the release of IL-13, IL-5, and IL-4, which play a vital role in eosinophilia induction, goblet cell hyperplasia, and IgE synthesis. This review critically examines IL-25's role in maintaining intestinal barrier integrity and modulating regulatory immune responses. This review addresses how IL-25 integrates signals from the epithelial interface, immune cells, and gut microbiota to calibrate appropriate host defense while preventing pathological inflammation. Furthermore, this paper presents recent evidence supporting IL-25's therapeutic potential, both as a potential adjuvant therapy to enhance parasite clearance and as a modulator of inflammatory conditions where type 2 immunity proves deficient.