Neonatal CARD14-Associated Papulosquamous Eruption: Response to Secukinumab During Infancy.

Neonatal erythroderma is a rare but serious condition characterized by generalized erythema and scaling present from birth or shortly after. We report a case of neonatal erythroderma in a 3-week-old male related to a heterozygous mutation in the CARD14 gene. The successful use of secukinumab adds an additional case to underscore the potential of targeted biologic therapies in treating severe neonatal inflammatory conditions.