Unexplained cardiac hypertrophy as a clue to plasma cell tumour: a case study.

Initial diagnosis: A 60-year-old male presented with initial diagnosis chest tightness, fatigue, and arrhythmia. Indications for plasma cell tumour: Initial imaging suggested amyloidosis due to myocardial thickening. Left ventricular hypertrophy and delayed enhancement on Magnetic Resonance Imaging (MRI), along with an elevated κ:λ ratio, raising suspicion for a plasma cell tumour. Confirmation of the plasma tumour: Further diagnostic tests, including immunofixation electrophoresis and myocardial biopsy, confirmed a plasma cell tumour. The patient was diagnosed with light chain (AL) amyloidosis, a subtype of plasma cell tumor, confirmed by bone marrow biopsy and immunohistochemistry. Treatment: Treatment with bortezomib, dexamethasone, and daratumumab resulted in significant symptomatic improvement.

Conclusion

This case underscores the importance of considering plasma cell disorders in unexplained cardiac hypertrophy and highlights the need for early diagnostic strategies and targeted therapies.