Blood purification · 2019
Hourly Fluid Balance in Patients Receiving Continuous Renal Replacement Therapy.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Naorungroj Thummaporn, Neto Ary Serpa, Zwakman-Hessels Lara, Yanase Fumitaka, Eastwood Glenn, Bellomo Rinaldo
Аннотация
INTRODUCTION: Little is known about early (first 48 h) hourly and cumulative fluid balance (FB) during continuous renal replacement therapy (CRRT).
OBJECTIVES: To study the characteristics and outcome associations of early hourly and cumulative FB.
METHODS: We studied FB in CRRT patients (2016-2018).
RESULTS: Among 350 patients, mean hourly FB became negative after 20 CRRT hours, but within 6 CRRT hours in patients with baseline fluid overload. A negative early FB was never achieved in patients receiving vasopressor therapy (p < 0.001). Mortality was 31%. The percentage of hourly negative FB was independently associated with decreased ICU mortality. A time-weighted hourly FB between 18.5 and -33 mL/h was also significantly and independently associated with decreased mortality.
CONCLUSIONS: In CRRT patients, an early FB conservative approach is possible, modulated by patient characteristics, and associated with a low mortality. Moreover, avoidance of an early positive FB is associated with decreased mortality.
OBJECTIVES: To study the characteristics and outcome associations of early hourly and cumulative FB.
METHODS: We studied FB in CRRT patients (2016-2018).
RESULTS: Among 350 patients, mean hourly FB became negative after 20 CRRT hours, but within 6 CRRT hours in patients with baseline fluid overload. A negative early FB was never achieved in patients receiving vasopressor therapy (p < 0.001). Mortality was 31%. The percentage of hourly negative FB was independently associated with decreased ICU mortality. A time-weighted hourly FB between 18.5 and -33 mL/h was also significantly and independently associated with decreased mortality.
CONCLUSIONS: In CRRT patients, an early FB conservative approach is possible, modulated by patient characteristics, and associated with a low mortality. Moreover, avoidance of an early positive FB is associated with decreased mortality.