Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025
Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model.
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Ikeda Masato, Haruhara Kotaro, Maruyama Yukio, Tanaka Naoko, Kusanagi Risa, Sakamaki Yuri, Hagiwara Hitomi, Yokoo Takashi
Аннотация
INTRODUCTION: The efficacy of peritoneal lavage monotherapy using PD solution for severe peritonitis remains unproven.
METHODS: We evaluated the effects of 3-times and 6-times lavage using low GDP neutral PD solution on a Methicillin-sensitive Staphylococcus aureus (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats.
RESULTS: Compared to the lethal peritonitis model without lavage, both 3-times and 6-times lavage significantly reduced 24-h mortality, effluent FDP and creatinine concentrations. Furthermore, 6-times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0-times and 3-times lavage groups. The effluent viable bacterial counts showed significant step-ladder decreases with an increasing number of the lavages.
CONCLUSION: We demonstrated for the first time that lavage monotherapy using PD solution reduces mortality and severity in a lethal peritonitis model by rapidly eliminating bacteria without antibiotic use.
METHODS: We evaluated the effects of 3-times and 6-times lavage using low GDP neutral PD solution on a Methicillin-sensitive Staphylococcus aureus (MSSA) lethal peritonitis model rats without antibiotic use. Changes in effluent viable bacteria numbers dependent on lavage frequency were determined in a further 10 rats.
RESULTS: Compared to the lethal peritonitis model without lavage, both 3-times and 6-times lavage significantly reduced 24-h mortality, effluent FDP and creatinine concentrations. Furthermore, 6-times lavage significantly prevented the rough fur development, intraabdominal adhesion, and pus formation which developed in both the 0-times and 3-times lavage groups. The effluent viable bacterial counts showed significant step-ladder decreases with an increasing number of the lavages.
CONCLUSION: We demonstrated for the first time that lavage monotherapy using PD solution reduces mortality and severity in a lethal peritonitis model by rapidly eliminating bacteria without antibiotic use.