Nature reviews. Immunology · 2024

Neuroinflammation in Alzheimer disease.

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Heneka Michael T, van der Flier Wiesje M, Jessen Frank, Hoozemanns Jeroen, Thal Dietmar Rudolf, Boche Delphine, Brosseron Frederic, Teunissen Charlotte, Zetterberg Henrik, Jacobs Andreas H, Edison Paul, Ramirez Alfredo, Cruchaga Carlos, Lambert Jean-Charles, Laza Agustin Ruiz, Sanchez-Mut Jose Vicente, Fischer Andre, Castro-Gomez Sergio, Stein Thor D, Kleineidam Luca, Wagner Michael, Neher Jonas J, Cunningham Colm, Singhrao Sim K, Prinz Marco, Glass Christopher K, Schlachetzki Johannes C M, Butovsky Oleg, Kleemann Kilian, De Jaeger Philip L, Scheiblich Hannah, Brown Guy C, Landreth Gary, Moutinho Miguel, Grutzendler Jaime, Gomez-Nicola Diego, McManus Róisín M, Andreasson Katrin, Ising Christina, Karabag Deniz, Baker Darren J, Liddelow Shane A, Verkhratsky Alexei, Tansey Malu, Monsonego Alon, Aigner Ludwig, Dorothée Guillaume, Nave Klaus-Armin, Simons Mikael, Constantin Gabriela, Rosenzweig Neta, Pascual Alberto, Petzold Gabor C, Kipnis Jonathan, Venegas Carmen, Colonna Marco, Walter Jochen, Tenner Andrea J, O'Banion M Kerry, Steinert Joern R, Feinstein Douglas L, Sastre Magdalena, Bhaskar Kiran, Hong Soyon, Schafer Dorothy P, Golde Todd, Ransohoff Richard M, Morgan David, Breitner John, Mancuso Renzo, Riechers Sean-Patrick

Аннотация

Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.

Предметные рубрики MeSH

Humans Alzheimer Disease Animals Neuroinflammatory Diseases Inflammation Immunity, Innate

Neuroinflammation in Alzheimer disease.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH