Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium.

SIGNIFICANCE: Optical polarimetry is an emerging modality that effectively quantifies the bulk optical properties that correlate with the anisotropic structural properties of cardiac tissues. We demonstrate the application of a polarimetric tool for characterizing healthy and fibrotic human myocardial tissues efficiently with a high degree of accuracy.

AIM: The study was aimed to characterize the myocardial tissues from the left ventricle and right ventricle of N  =  7 control and N  =  10 diseased subjects. The diseased subjects were composed of two groups: N  =  7 with rheumatic heart disease (RHD) and N  =  3 with myxomatous valve (MV) disease.

APPROACH: A portable, affordable, and accurate linear polarization-based diagnostic tool is developed to measure the degree of linear polarization (DOLP) of the myocardial tissues while working at a wavelength of 850 nm.

RESULTS

The sensitivity, specificity, and accuracy of the polarimetric tool in distinguishing the control group from the RHD group were found to be 73.33%, 76.92%, and 75%, respectively, and from the MV group were 91.6%, 62.5%, and 80%, respectively, which demonstrates the efficacy of the polarimetric tool to distinguish the healthy myocardial tissues from diseased tissues.

CONCLUSIONS

We have successfully developed a polarimetric tool that can aid cardiologists in characterizing the myocardial tissues in conjunction with endomyocardial biopsy. This work should be followed up with experiments on a large cohort of control and diseased subjects. We intend to create and develop a probe to quantify the DOLP of in vivo heart tissue during surgery.