Case Report: Complete remission after radiotherapy in two cases of locally advanced extramammary Paget's disease of the perineum.

PURPOSE: Reports on the efficacy of radiotherapy for perineal extramammary Paget's disease (EMPD) are limited. We present two cases of locally advanced perineal EMPD successfully treated with radiotherapy.

METHODS

A retrospective review was conducted on the clinical presentation, management, and outcomes of two patients with locally advanced, inoperable perineal EMPD who received radiotherapy at our hospital.

RESULTS

Both patients achieved complete clinical and radiological remission following radiotherapy. At the last follow-up in January 2026, neither patient showed any evidence of local recurrence or distant metastasis.

CONCLUSIONS

Radiotherapy is an effective and well-tolerated definitive treatment modality for patients with locally advanced EMPD who are not candidates for or who decline surgical resection.