Early response with clomipramine in obsessive compulsive disorder--a placebo controlled study.

1. Clomipramine has been found to be effective in the treatment of obsessive compulsive disorder (OCD) in nine placebo controlled studies whereas other conventional antidepressants lacking 5-HT reuptake inhibiting properties do not appear to be effective. 2. The placebo response rate in OCD is very low as is seen in the placebo controlled study of the efficacy of clomipramine 75mg in 14 patients suffering from OCD reported here. 3. Response appears early in treatment when compared with response of depression to antidepressants.