Proteins · 2017
Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Higgins Melanie A, Hamilton Aileen M, Boraston Alisdair B
Аннотация
Streptococcus pneumoniae harbors a significant number of transporters, including phosphotransferase (PTS) systems, allowing the bacterium to utilize a number of different carbohydrates for metabolic and other purposes. The genes encoding for one PTS transport system in particular (EIIfuc ) are found within a fucose utilization operon in S. pneumoniae TIGR4. Here, we report the three-dimensional structures of IIAfuc and IIBfuc providing evidence that this PTS system belongs to the EIIman family. Additionally, the predicted metabolic pathway for this distinctive fucose utilization system suggests that EIIfuc transports the H-disaccharide blood group antigen, which would represent a novel PTS transporter specificity. Proteins 2017; 85:963-968. © 2016 Wiley Periodicals, Inc.
Предметные рубрики MeSH
ABO Blood-Group SystemBacterial ProteinsBinding SitesBiological TransportCloning, MolecularCrystallography, X-RayEscherichia coliFucoseGene ExpressionMembrane Transport ProteinsMetabolic Networks and PathwaysModels, MolecularOperonPhosphoenolpyruvate Sugar Phosphotransferase SystemProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsProtein IsoformsRecombinant ProteinsStreptococcus pneumoniae