Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis.

BACKGROUND

Depression is a mental disorder that affects a large part of the world's population. DHEA is a hormone that has long been attributed to the ability to improve depressive symptoms. However, few studies were conducted with depression individuals not resulting from other medical conditions.

OBJECTIVE

To investigate whether DHEA is more effective than placebo in the treatment of depressive symptoms in subjects with depression not resulting from other psychiatric or medical comorbidities.

METHODS

An electronic search was carried out using the keywords Dehydroepiandrosterone (Mesh) AND Depression (Mesh) in the following databases: Medical Literature databases Analysis and Retrieval System Online (Medline), Excerpta Medical Database (EMBASE), Latin American and Caribbean Health Sciences (LILACS) and the Cochrane Library through their website for relevant publications until June 2018. Only randomized clinical trials were included. The critical appraisal of the articles was performed using the Risk of Bias Tool from Cochrane Collaboration.

RESULTS

The meta-analysis applied in this review pointed to a significant effect in favor of treatment with DHEA compared to placebo.

CONCLUSION

DHEA may be one more effective alternative between the drugs used in the treatment of depression.