Science (New York, N.Y.) · 2007

Draft genome of the filarial nematode parasite Brugia malayi.

Сравнительное исследованиеСтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Ghedin Elodie, Wang Shiliang, Spiro David, Caler Elisabet, Zhao Qi, Crabtree Jonathan, Allen Jonathan E, Delcher Arthur L, Guiliano David B, Miranda-Saavedra Diego, Angiuoli Samuel V, Creasy Todd, Amedeo Paolo, Haas Brian, El-Sayed Najib M, Wortman Jennifer R, Feldblyum Tamara, Tallon Luke, Schatz Michael, Shumway Martin, Koo Hean, Salzberg Steven L, Schobel Seth, Pertea Mihaela, Pop Mihai, White Owen, Barton Geoffrey J, Carlow Clotilde K S, Crawford Michael J, Daub Jennifer, Dimmic Matthew W, Estes Chris F, Foster Jeremy M, Ganatra Mehul, Gregory William F, Johnson Nicholas M, Jin Jinming, Komuniecki Richard, Korf Ian, Kumar Sanjay, Laney Sandra, Li Ben-Wen, Li Wen, Lindblom Tim H, Lustigman Sara, Ma Dong, Maina Claude V, Martin David M A, McCarter James P, McReynolds Larry, Mitreva Makedonka, Nutman Thomas B, Parkinson John, Peregrín-Alvarez José M, Poole Catherine, Ren Qinghu, Saunders Lori, Sluder Ann E, Smith Katherine, Stanke Mario, Unnasch Thomas R, Ware Jenna, Wei Aguan D, Weil Gary, Williams Deryck J, Zhang Yinhua, Williams Steven A, Fraser-Liggett Claire, Slatko Barton, Blaxter Mark L, Scott Alan L

Аннотация

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during approximately 350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.

Предметные рубрики MeSH

Animals Brugia malayi Caenorhabditis Drosophila melanogaster Drug Resistance Filariasis Genome, Helminth Humans Molecular Sequence Data

Draft genome of the filarial nematode parasite Brugia malayi.

Ошибки и ограничения

Аннотация

Предметные рубрики MeSH