Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2016
[Role of the lymphocyte transformation test in the evaluation of metal sensitization].
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Summer B, Ständer S, Kapp F, Thomas P
Аннотация
BACKGROUND: The lymphocyte transformation test is used to determine T‑cell sensitization, whereby its benefit has been controversially discussed in the past.
OBJECTIVES: What role does the lymphocyte transformation test have in the detection of metal sensitization?
METHODS: Based on the current literature and our own work, the state of knowledge regarding the lymphocyte transformation test is presented.
RESULTS: In several studies, it was found that the lymphocyte transformation test, especially concerning metals, has sufficient specificity and sensitivity. Various modified test protocols that were more recently developed are also presented in this article. The lymphocyte transformation test is an assay which must be evaluated by the operating laboratories.
CONCLUSIONS: To detect metal sensitization, the lymphocyte transformation test can be useful especially in situations in which exposure did not occur via the skin, but from inside the body (e. g. by metal implants).
OBJECTIVES: What role does the lymphocyte transformation test have in the detection of metal sensitization?
METHODS: Based on the current literature and our own work, the state of knowledge regarding the lymphocyte transformation test is presented.
RESULTS: In several studies, it was found that the lymphocyte transformation test, especially concerning metals, has sufficient specificity and sensitivity. Various modified test protocols that were more recently developed are also presented in this article. The lymphocyte transformation test is an assay which must be evaluated by the operating laboratories.
CONCLUSIONS: To detect metal sensitization, the lymphocyte transformation test can be useful especially in situations in which exposure did not occur via the skin, but from inside the body (e. g. by metal implants).