[Role of the lymphocyte transformation test in the evaluation of metal sensitization].

BACKGROUND

The lymphocyte transformation test is used to determine T‑cell sensitization, whereby its benefit has been controversially discussed in the past.

OBJECTIVES

What role does the lymphocyte transformation test have in the detection of metal sensitization?

METHODS

Based on the current literature and our own work, the state of knowledge regarding the lymphocyte transformation test is presented.

RESULTS

In several studies, it was found that the lymphocyte transformation test, especially concerning metals, has sufficient specificity and sensitivity. Various modified test protocols that were more recently developed are also presented in this article. The lymphocyte transformation test is an assay which must be evaluated by the operating laboratories.

CONCLUSIONS

To detect metal sensitization, the lymphocyte transformation test can be useful especially in situations in which exposure did not occur via the skin, but from inside the body (e. g. by metal implants).